TRANSFER FACTOR® TRI-FACTOR® FORMULAS™
MORE THAN 3,000 STUDIES
SCIENTISTS FROM MORE THAN SEVENTY NATIONS HAVE CONDUCTED RESEARCH ON TRANSFER FACTOR
Target the highest health risks with Targeted Transfer Factors
The second development in Transfer Factor discoveries includes the extraction of Transfer Factors from egg yolks. The discovery of adding Transfer Factors from egg yolks to Transfer Factors from colostrum is proven to increase natural killer cell activities by 283 percent. This gave rise to a wide variety of products using Transfer Factor E-XF. One of those lines includes targeted Transfer Factors and other nutrients that provide support to address the specific needs of particular systems of the body.Each system or organ of your body has specific nutrient requirements. If these nutrient requirements are not met, that system or organ becomes vulnerable to toxins and a wide variety of foreign invaders.
The Center for Disease Control (CDC) keeps statistics about disease in the United States. These statistics tell us what the most common mortalities are. See Chart
4Life developed five products that target the most helpful nutrients based in part on mortality statistics. Now we are not saying that these products cure or prevent disease. They only claim to target nutrient support, such as Transfer Factor E-XF, to structures and functions that are known to improve or support better health or reduce your risks. Because 4life researched and developed these products, they give you the opportunity to take an effective proactive approach to your health that can make the difference in your life, just like it has for so many others.
SOURCE: Xu JQ, Kochanek KD, Tejada-Vera B. Deaths: preliminary data for 2007. Natl Vital Stat Rep 2009;58(01). Hyattsville, MD: US Department of Health and Human Services, CDC; 2009. Available at http://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_01.pdf.
Alternate Text: The figure above shows age-adjusted death rates for the 10 leading causes of death, based on data from the National Vital Statistics System for the United States during 2006 and 2007.
Transfer Factors are small molecules that intelligently modulate immune system activities such as T Cells, Natural Killer (NK) cells, and Immunoglobulin Antibodies (IgA). They were discovered in the 1940s by Dr. H. Sherwood Lawrence. Recently, 4Life Research discovered that pure transfer factors can be extracted from colostrum and egg yolks and received patents for the processes. 4Life Transfer Factor products are health nutrition supplements that use Transfer Factors to support the immune system better than any other source known at this time. Independent comparison studies show other forms of extraction are relatively costly and ineffective. As with many revolutionary breakthroughs that threaten convention, Transfer Factors are being met with sometimes criminal contempt. 4Life Transfer Factors are natural peptide molecules made in our bodies that speed up and modulate recognition, response, memory, and resting of immune system activities. Taking 4Life Transfer Factors effectively helps the immune system fight off threats, foreign invaders, and preserve energy. They are transferred from a mother who breast feeds to her new born infant to support the infant's immune system. The need for 4Life Transfer Factors in children and adults comes from the interplay of genetic and environmental invaders that weaken and/or over-activate our immune systems responses to threats to our health.
Transfer Factors are very small components naturally found in colostrum, a baby’s first milk from its mother. Through a special, patented (licensed to 4Life) extraction process, we are now able to collect powerful transfer factor molecules from the cow's first milk, dry them, and then encapsulate them for human consumption. This patented process is very important and sets 4Life™ Transfer Factor™ apart from any other product. The Transfer Factor™ collected from this process is a purified extract containing transfer factor molecules.
Transfer Factor provides "immune data" collected from the mother’s own immune system and then passed on to her baby. The mother transfers valuable immunity information to be used by the new life to assist in staving off infection and disease. These powerful immunity agents have been identified and are called Transfer Factors. To keep your body healthy, your immune system must do three very important things each time your body comes in contact with a pathogen: First it must first recognize the pathogen as a threat to the body; second, it must then attack and kill off the threat; and third, it must remember that pathogen so that your body can rid itself quickly of it the next time it is attacked. It is the identification process of the immune system that is so critical. If your body can identify a pathogen quickly, it can mount a response against it quickly. By transferring information from cell to cell, Transfer Factors serve as "teachers" of new cells, thereby ensuring a stronger immune system capable of withstanding our often harsh environment.
Transfer Factor products have helped people with Allergies, Arthritis, Asthma, Acne & Skin Conditions, Autism, Bronchitis, Burns, all types of Cancer including Breast Cancer, Cholesterol Reduction, Coughs, Colds and Flu, Diabetes, Eczema, Fibromyalgia & Back pain, Heart Problems, Hypertension, HIV/Aids, Irritable Bowel Syndrome, Joint & Muscle pains, Low Libido, Low Energy, Loss of Appetite & Chronic Fatigue, Menopause, Migraine, Morning Sickness during Pregnancy, PMS, Post Accident Care, Psoriasis, Sinusitis, Skin Infections, Thyroid, Tumor, Ulcer, Weight Gain, Weight Loss, etc.
Transfer Factor is an excellent natural product for Immune System Education, Immune Modulation (Balancing) as well as Immune Boosting, offering the body natural alternatives for preventative health. Transfer Factor helps support the body’s Immune System- NK cells and other immune cells (B cells, T-cells) to fight infection, viruses, cancer (including late stage cancer), hepatitis, allergies and auto immune system problems.
DESCRIPTION: Transfer Factors are small peptides of approximately 44 amino acids that “transfer” cell-modulated immunity from immune donors to non-immune recipients. 4Life Transfer Factor® products are derived from egg yolk and cow colostrum extracts that contain antigen information. NanoFactor™ concentrate contains molecules smaller than Transfer Factors, stimulating T-Cell activity and providing additional immune information to non-immune recipients. Combined, these compounds comprise the Tri-Factor Formula, which offers the broadest spectrum immune support available.
NanoFactor Technology has several patents pending. Transfer Factor and NanoFactor educate the immune system to recognize self from non-self, thus supporting healthy immune system balance. Because they instruct the immune system to act appropriately, these compounds are effective in supporting normal inflammation response in the body, a key to healthy body system function. 4Life Transfer Factor Plus Tri-Factor Formula combines Transfer Factor E-XF™ and NanoFactor with a proprietary formulation of innate and adoptive immune system enhancers such as Inositol Hexaphosphate, Cordyceps, Beta Glucans, Maitake and Shiitake Mushrooms. These ingredients work together to trigger and enhance the various immune protective mechanisms of the body. Clinical studies show that 4Life Transfer Factor Plus Tri-Factor Formula can increase Natural Killer cell activity up to 437 percent above baseline*, and that NanoFactor stimulates T-Cell activity to improve the immune system’s ability to stay in balance. *Blind Independent study conducted by Dr. Anatoli Vorobiev, Head of Immunology at the Russian Academy of Medical Science*
THE BENEFITS OF TRANSFER FACTOR
*** Stimulates and modulates the Immune System*** Shorten the duration of infection
*** Antivirus, Antibacterial, Antifungal, Anti-inflammatory
*** Antioxidant, Anticancer, Anti-intestinal parasites
*** Reduces cell degeneration (anti-aging)
*** Provides energy, stamina and vitality
*** Lower LDL (bad cholesterol)
*** Reduces heart diseases and protects the prostate
*** Helps prevent kidney and bladder stones buildup
*** Helps teeth and gum disorders, allergies
*** Improves cardiovascular system
*** Improves memory and night vision
Transfer Factors are tiny messenger molecules that transfer immunity information from one entity to another, such as between a breastfeeding mother and her newborn infant.
NanoFactor™ extract is 4Life's patent-pending extract of immune system-enhancing nanofractions. It helps “fine-tune” immune system function so that immune cells know when to act, how to act, and when to rest.
The extraction process for transfer factors from egg sources is protected by US patent 6,468,534; and the combining process for colostrum and egg sources is protected by U.S. patent 6,866,868.
Independent laboratory studies show that 4Life Transfer Factor Tri-Factor Formula can boost immune system effectiveness by raising Natural Killer cell function 283 percent.
4Life Transfer Factor products are featured in the 2003, 2004, 2005, 2006, and 2007 Physicians' Desk Reference For Nonprescription Drugs and Dietary Supplements, the standard supplement guide for physicians that can be found in physician offices, hospitals, and pharmacies throughout the United States.
4Life Transfer Factor® products have been recommended by the Russian Federation for use in hospitals and clinics. This historic announcement was a result of ten separate scientific trials and two experimental studies extolling the benefits of 4Life Transfer Factor products.
We live in a world where stress, pollution, poor diet and new strains of “superbugs” are constantly undermining people’s immune systems and leading to more frequent or prolonged infection. People everywhere are looking for solutions to keep their bodies and immune systems operating at peak performance.
Mothers, fathers, teens, young adults, children and seniors from every walk of life are facing more and more challenges to their health. Everyone who needs immune system support or who simply want to maintain their everyday health, can benefit from taking Transfer Factor products.Dr David Markowitz, a pediatrician who practices in Maine has finished a review of his first twelve months’ experience with transfer factor supplementation. The study found that eighty-eight children who used Transfer Factor isolates daily at the recommended doses for six or more months showed a 74% reduction in reported illness and an 84% reduction in antibiotic use.
Taking Transfer Factor on a daily basis can support our immune system's ability to fight invaders and help us lead healthier lives. Transfer Factor is for all of us. It is safe and suitable for all ages; infants through to elderly. Transfer Factor is Nature's Answer for today's health challenges.
Nature's health is best suggestion by Doctors
We are living at a time when we have tremendous challenges to our health, while the opportunities for longer and healthier life have never been better. People in the U.S. are now living longer due to the technology of public health improvements including sewage treatment, food preservation, childbirth sanitation and acute care medicine. However, the incidence of chronic disease; cancer, heart and lung diseases, and diabetes are all increasing.
Over the last 40 years advances in biology and biochemistry have revealed to us the intricate chemical processes that make the human body function. Medical science has learned to grow a test tube embryo and implant it successfully. Surgical procedures using lasers and endoscopes have achieved remarkable success. Organ transplants and joint replacement have become routine and we hear about new high-tech drugs daily. So why do we suffer even though we are in the midst of seemingly unlimited healthcare resources? The problem is our current health care system- dehumanizing, outdated system that rewards illness and treats symptoms rather than causes. The solution is nutrition to provide the life forces with all the proper nutrients to build, fuel, and repair your body. Not only is nutrition an excellent tool for preventing disease, but it can also heal or improve certain conditions. Instead of using drugs and surgery to remove the symptoms, nutrition can often clear up the problem itself.
Take control of your health. Symptoms are signs that the body is in some way out of balance. When your symptoms are aggravated, you may be doing something which is aggravating them. When symptoms disappear you are probably doing something right. Listen to what your body is telling you. Listen, become wise and enjoy good health.
Transfer Factors and Immunology Pioneer
The knowledge of Transfer Factors owes its existence to immunology pioneer Dr. H. Sherwood Lawrence. In 1949, Lawrence discovered that by injecting an extract from the leukocytes of someone previously infected with tuberculosis into someone as of yet uninfected with it, immunity was conferred to the recipient, sparing him/her from developing the infection. Dr. Lawrence named the extract transfer factor and the possibility of sharing natural immunity between people and even animals and people became real.
Dr. Lawrence graduated from the NYU School of Medicine in 1943. From 1943 to 1949, he served as a medical intern and then as a medical officer with the U.S. Navy, seeing activity in southern France and Japan and receiving two Bronze Stars.
He served on the faculty of the NYU School of Medicine from 1947 to 1959 and from 1959 until his retirement in 2000, was head of infectious diseases and immunology at NYU. He also served as co-director of medical services at Bellevue and New York University hospitals from 1964 to 2000, director of the NYU cancer center from 1974 to 1979 and director of the NYU AIDS research center from 1989 to 1994.
He was a member of the National Academy of Sciences and honorary chairman of the International Transfer Factor Society (ITFS), a scholarly organization committed to the worldwide exchange of information pertaining to the immunologic properties of leukocyte dialysates.
Regrettably, Dr. Lawrence passed away at the age of 87 in Manhattan on April 5, 2004.
This chart gives you a visual of the powerful immune information contained in one Transfer Factor capsule.
| TF in Colostrum vs. Pure Transfer Factor Extract |
Although colostrum has many excellent health benefits, the lactose and specific antibodies contained in it can cause reactions in some people. Because these molecules are much larger than the transfer factor molecules, they are filtered out of the colostrum by 4Life®’s patented ultra-filtration process, leaving only the pure Transfer Factors and the even smaller NanoFactors™. Transfer Factors have the ability to communicate immune intelligence from cell to cell. The NanoFactors™ have been found to enhance the balancing of the immune response.
This product represents 4Life's highest level of immune system support. 4Life® Transfer Factor Plus Tri-Factor Formula combines the intelligence of Transfer Factor E-XF™, the intuition of NanoFactor™ extract, and the added support of our Cordyvant™ blend to provide the ultimate in immune system support for your body. The proprietary Cordyvant blend features known immune-supporting ingredients such as maitake and shiitake mushrooms, cordyceps, inositol hexaphosphate, beta glucans, beta sitosterol, and olive leaf extract.
Cordyvant combines ingredients known to enhance the innate immune system, our first and instinctive response against foreign invaders. It includes:
- Maitake and Shiitake Mushrooms—long known to support cellular function (immune system) and other healthy systems.
- Cordyceps—rich in polysaccharides, which help activate immune system response.
- Inositol Hexaphosphate—gaining attention for its preventative immune power.
- Beta Glucans—an important immune cell stimulator. They are the “wake-up” call to white blood cells for healthy function.
- Beta Sitosterol—a phytosterol that has been shown to help activate immune system response.
- Olive Leaf Extract—may be instrumental in slowing the duplication of cells.
Research shows that the immune building effects of this revolutionary product increase immune system effectiveness by 437 percent!
Source : Jeunesse Inc, Institute of Longevity Medicine, California, USA 7 Years Study on 198 popular products (1992 - 1999)
.:. 30 times more effective than royal jelly, ginseng, sea cucumber, green tea. Wheat grass, gingko
.:. 29 times more effective than noni and aloe vera
.:. 19 times more effective than colostrum
.:. 15 times more effective than cordyceps
.:. 10 times more effective than echinacea and shiitake
.:. 9 times more effective than spirullina
.:. 6 times more effective than manggosteen
IgA antibodies, produced by plasma cells, are highly specific proteins used by the immune system to bind and neutralize foreign invaders. IgA bathes the surface of the mucous membranes. These y-shaped proteins bind to invaders, preventing them from attaching and passing through the mucous lining into the tissues and bloodstream of the body.
.:. Boosts B-cell production of IgA antibodies, increasing the body's defense
.:. Boosts effectiveness of Natural killer cells, increasing your immune system's front line of protection
.:. Provides critical protection at one of the most common entry points for potential immune system threats
.:. Works quickly within the body improves immune system protection by increasing vital antibody production and NK cell effectiveness
.:. Supports immune system health and overall wellness, even for those who are healthy
TRUSTED BY DOCTORS IN RUSSIA @ RUSSIAN ACADEMY OF MEDICAL AND TECHNICAL SCIENCE
SANDY, UTAH (October 1, 2004) - In an unprecedented announcement in the history of network marketing, 4Life announced today that 4Life Transfer Factor products as immune modulators have been approved for use in hospitals and clinics in the Russian Federation. The results of ten separate clinical trials and two experimental studies on 4Life Transfer Factor products were combined in a Methodological Document that was approved by the Ministry of Health, which now allows doctors to recommend 4Life Transfer Factor Classic and 4Life Transfer Factor Plus Advanced products to their patients.
***First Dietary Supplement Approved for Use by Doctors and Hospitals in Russia***
Commenting on this remarkable achievement, David Lisonbee, CEO of 4Life stated, “To my knowledge, this is the first time in the history of this industry that a network marketing company or any other dietary supplement company has had one of its dietary supplements approved for use in hospitals in Russia. The Russian Ministry of Health is the equivalent of the Food and Drug Administration in the United States. Doctors and scientists from Russia have been working jointly with scientists from 4Life for several years to arrive at this accomplishment. This approval establishes a new roll of dietary supplements in the Russian health care system.
***Remarkable Response from Russian Academy of Medical Sciences***
In another sector of research of 4Life Transfer Factor, Dr. Kisielevsky of the Russian Academy of Medical Sciences stated, “The 4Life sample [Transfer Factor Advanced Formula] activated NK (natural killer) cell activity more than the Interleukin-2 (IL2) drug we used as the standard.” This discovery has attracted the attention of The International Scientific and Technical Center (ISTC) of Russia.
***Scientists from Several Countries Join Forces for Additional Clinical Studies of Transfer Factor***
The ISTC of Russia is a member of a joint international project with other health agencies of Japan, Europe and the US. The objective of the international project is to combine efforts in finding improved immunotherapies. Following the discoveries from the NK cell testing, the scientists of 4Life have been invited to join the project. 4Life Transfer Factor as an immune modulator will be further researched in this international forum. The cost of the studies will be paid by the ISTC.
***Worldwide Ramification***
Speaking of this benchmark achievement, Dr. Calvin McCausland, VP of Research of 4Life, and Dr. Emma Oganova, 4Life/Eurasia President, jointly expressed that because of the acceptance by such a reputable organization and doctors from Russia and other major countries, 4Life Transfer Factor will gain wider acceptance in the professional and private sectors as a superior immune system enhancing product. The worldwide ramifications to this acceptance are just beginning.
NanoFactor extract: Nanofractions are low-weight molecules found in the immune systems of certain mammals and birds. They possess natural intuition and function as part of the complex “command and control” network of the immune system. NanoFactor is 4Life’s patent-pending extract of nanofractions from cow colostrum. NanoFactor helps immune cells know when to act, how to act, and when to rest.
While Transfer Factors and nanofractions each provide effective immune support on their own, intelligence and intuition are both needed for optimal immune response. 4Life Transfer Factor Tri-Factor Formula brings together the intelligence of 4Life Transfer Factor and the intuition of NanoFactor, to regulate, boost, and balance the immune system… according to what your body needs.
Cordyvant blend: Cordyvant contains ingredients that support the innate immune system, your first and instinctive response when your body is threatened. This blend contains known immune system nutrients, including: maitake and shiitake mushrooms, cordyceps, inositol hexaphosphate, beta glucans, soya bean extract, and olive leaf extract.
Scientifically Studied: 4Life Transfer Factor Plus Tri-Factor Formula was developed by 4Life researchers and scientists in an effort to maximize immune system support. Results of an independent study conducted at the Russian Academy of Medical Science conclusively showed that 4Life Transfer Factor Plus Tri-Factor Formula propelled Natural Killer (NK) cell activity to a remarkable 437 percent above normal immune system response.
Imagine an all natural substance that works by "teaching" your own immune system to identify infectious agents that attack your body every day (bacteria, viruses, fungus, and parasites).
4Life™ Research, makes available just such a products. An extraordinary line of Transfer Factor™ products, including the revolutionary Transfer Factor Plus™ for a healthy, intelligent immune system capable of supporting you during times when you might be confronted with challenges to your health.
Immune support that is not limited to just the medical challenges but to those ordinary and extra ordinary stress of life. Today more than ever, we must be prepared to deal with crisis that have a powerful effect on us psychologically and that can physically effects us at a cellular level.
A strong immune system is our first line of defense against disease. Transfer factors are special messenger molecules, that can offer support to our immune system, to help us achieve and maintain a more healthy lifestyle.
Realizing that your health, your stress levels, sometimes even your weight and quality of life are effected by your immune system should motivate you to make your system strong. Well, you can raise your immune IQ significantly with Transfer Factor™ and Transfer Factor Plus™. These exceptional products have been proven (by independent laboratory test) to revitalize your immune system substantially. This could allow your body to fight infections, diseases and stress more effectively.
Associate Clinical Professor W.H.O (World Health Organization) Western Europe, Dr. Darryl See received his degree from the University of California, Irvine. Academic appointments include: Assistant/Associate Clinical Professor of Medicine: Investigator, California Collaborative Treatment Group: and Infectious Diseases Consultant, Liver Transplantation Service.
He has received contracts, grants and research awards from Harvard Biotechnology, Pfizer Pharmaceuticals, Upjohn Pharmaceuticals, Roche Molecular Systems, National Institute of Health, Department of Defense, and more.
Increased tumor necrosis factor alpha (TNF-alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers.
Immunol Invest 2002 May, 31(2):137-53
See D, Mason S, Roshan R.
Center for Advanced Medicine, Encinitias, California 92024, USA.
Natural products may increase cytotoxic activity of Natural Killer Cells (NK) Tumor Necrosis Factor alpha (TNF-alpha) while decreasing DNA damage in patients with late-stage cancer. Pilot studies have suggested that a combination of Nutraceuticals can raise NK cell function and TNF-alpha alpha activity and result in improved clinical outcomes in patients with late stage cancer. The objective of the study is to determine if Nutraceuticals can significantly raise NK function and TNF levels in patients with late stage cancer. After informed consent was obtained, 20 patients with stage IV, end-stage cancer were evaluated (one bladder, five breast, two prostate, one neuroblastoma, two non-small cell lung, three colon, 1 mesothelioma, two lymphoma, one ovarian, one gastric, one osteosarcoma). Enhanced Transfer Factors (3 tablets 3 times per day), IMUPlus (non denatured milk whey protein, 40 gm/day); Intravenous (50 to 100 gm/day) and oral (1-2 gm/day) ascorbic acid; Agaricus Blazeii Murill teas (10 gm/day); Immune Modulator Mix (a combination of vitamin, minerals, antioxidants and immune-enhancing natural products); nitrogenated soy extract (high levels of genistein and dadzein) and Andrographis Paniculata (500 mg twice, daily) were used. Baseline NK function by standard 4 h 51 Cr release assay and TNF alpha and receptor levels were measured by ELISA from resting and phytohemagglutinin (PHA) stimulated adherent and non-adherent Peripheral Blood Mononuclear Cell (PBMC). Total mercaptans and glutathione in plasma were taken and compared to levels measured 6 months later. Complete blood counts and chemistry panels were routinely monitored. As of a mean of 6 months, 16/20 patients were still alive. The 16 survivors had significantly higher NK function than baseline (p < .01 for each) and TNF-alpha levels in all four cell populations studied (p < .01 for each). Total mercaptans (p < .01) and TNF-alpha receptor levels were significantly reduced (p < .01). It was also observed that hemoglobin, hematocrit and glutathione levels were significantly elevated. The only toxicity noted was occasional diarrhea and nausea. The quality of life improved for all survivors by SF-36 form evaluation. An aggressive combination of immunoactive Nutraceuticals was effective in significantly increasing NK function, other immune parameters and hemoglobin from PBMC or plasma in patients with late stage cancers. Nutraceutical combinations may be effective in late stage cancers. Clinical outcomes evaluations are ongoing.
In vitro study
Ingredient 10 GM /ml NK Function
PBMC (Control) 25.6%
Zinc 26.8% NS
Proprietary Blend 59.9% 0.02
(Mushrooms etc)
Zinc +Prop. Blend 95.4 0.01
Transfer Factors alone 128.5% 0.01
Complete Prod. (Enhanced Transfer Factors) 273.6% 0.01
The sum of the individual product is less than the Complete Product (Enhanced Transfer Factors).
There is synergy in having a combination of Enhanced Transfer Factors.
Twenty patients, 12 men and 8 women, were selected for this in vivo study. The average age was 49.3. The twenty individuals were each level 3 or level 4 cancer patients. Each patient was basically sent home by his or her oncologist to die. The average life expectancy was 3.7 months. The protocol was to place each patient on 9 capsules per day of Enhanced Transfer Factors. The patients were given a number of other general nutrients*. After eight months, 16 of these individuals were still living and were either in remission, improving or stabilized.
The baseline for natural killer cell function was 6.4. Within 4 weeks the average NK Cell function was increased to 25.7 and in 6 months it increased to 27.6. This represented a 400% increase in NK Cell function. This is an ongoing study. This study has been submitted to a peer reviewed publication.
*Antioxidants, Digestive Enzymes, Probiotics and Multi-Vitamins.
JeunesseInc.
Institute of Longevity Medicine
11/5/99
PRELIMINARY REPORT (additional test results to follow)
Transfer Factor Testing
Background and rationale: 1) Cancer is the second leading cause of death in the US. The rate of nearly every type of cancer is on the rise. Despite billions of dollars in research, the mortality rate has remained nearly unchanged since the 1960’s using convention treatments such as radiation, surgery and chemotherapy. Thus, there is considerable interest in using immune modulation as an adjuvant for cancer therapy. Natural killer cells are particularly important in destroying cancer cells.
Purpose of study: 1) To determine the in vitro anti-cancer effects of Transfer Factors and enhanced transfer factors using PBMC isolated from human volunteers and assaying the increased ability of the NK cell population to kill K562 erythroleukemic cells.
Methods: 1) PBMC killing of K562 (erythroleukemic) cells
Results: 1) Transfer Factors increased NK-cell killing by 100% and Enhanced Transfer Factors by 250%.
Conclusions: Transfer Factors and Enhanced Transfer Factor induced immune-based lysis of K562 cells at a level unprecedented in the director’s experience or in the known medical literature. Since NK cell function is so crucial in killing cancer cells, these products are ideal candidates for cancer adjuvant therapy. In addition, NK cells form a first line of defense against infections from viruses and certain other microorganisms. Killing assays against K562 cells have also been correlated with increased activity against chronic and acute infections as well.
Darryl See, MD
Director, Bioassay Laboratory
Institute of Longevity Medicine
See D, Gurnee K, LeClair M
Americans consume billions of dollars worth of natural products each year. However, the toxicities and potential drug interactions of commonly used dietary supplements have not been closely evaluated. Additionally, claims of immune system enhancement, broad-spectrum anti-microbial activity and antioxidant action have not been sufficiently validated. To determine the potential for human cellular damage from the use of dietary supplements, toxicity in liver and peripheral blood mononuclear cells (PBMC) was evaluated in vitro. The effect of dietary supplements on cytochrome p450 system activity was tested because these liver enzymes are vital in the processing of many drugs, as well as normal substances. Therefore, any interference with this system by dietary supplements may lead to either elevated or diminished drug levels in the blood and may disrupt the metabolism of common substances. Natural killer (NK) cells are important in fighting cancers, viruses and certain bacteria. Therefore, the potential enhancement of NK cells by dietary supplements was tested to predict potential protection from these harmful elements. Free-radical (oxidative) damage is responsible for poor cellular function and premature aging. Thus, the capacity of dietary supplements to reduce these destructive processes was determined by increases in intracellular glutathione (GSH) levels. Viruses cause numerous illnesses in humans, ranging from the common cold to AIDS. Therefore, the potential antiviral activity of supplements was evaluated. Thus, the ideal supplements would be those that are non-toxic, cause no cytochrome p450 changes to any of the many enzymes in this system and are efficacious as defined by enhancement of NK function, antioxidant activity and protection against viruses. In this investigation, some dietary supplements had beneficial and some had detrimental effects. Only aloe, garlic and the three multiple-ingredient products containing glyconutrients were non-toxic, caused no cytochrome p450 activity and were effective in all three efficacy assays (NK cell enhancement, antioxidant activity and antiviral effect). Not all products that show potential in in vitro assays prove themselves clinically. However, the impressively positive results of these five products in this study have been and are being corroborated by clinical benefits in initial human studies.
The glyconutrients included in the study are a blend of plant polysaccharides that provide a nutritional source for the eight primary saccharides found in human glycoconjugate synthesis. These saccharides are utilized in the Golgi bodies of all cells to form important cell surface molecules and other signaling molecules called cytokines which support cell to cell communication functions essential to immune response and hormonal processes.
Immunol Invest 2002 May; 31(2):137-53
Increased tumor necrosis factor alpha (TNF-Alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers.
See D, Mason S, Roshan R.
Center for Advanced Medicine, Encinitias, California 92024, USA.
Natural products may increase cytotoxic activity of Natural Killer Cells (NK) Tumor Necrosis Factor alpha (TNF-Alpha) while decreasing DNA damage in patients with late-stage cancer. Pilot studies have suggested that a combination of Nutraceuticals can raise NK cell function and TNF-alpha activity and result in improved clinical outcomes in patients with late stage cancer. The objective of the study is to determine if Nutraceuticals can significantly raise NK function and TNF levels in patients with late stage cancer. After informed consent was obtained, 20 patients with stage IV, end-stage cancer were evaluated (one bladder, five breast, two prostate, one neuroblastoma, two non-small cell lung, three colon, 1 mesothelioma, two lymphoma, one ovarian, one gastric, one osteosarcoma). Enhanced Transfer Factors (3 tablets 3 times per day), IMUPlus (non denatured milk whey protein, 40 gm/day); Intravenous (50 to 100 gm/day) and oral (1-2 gm/day) ascorbic acid; Agaricus Blazeii Murill teas (10 gm/day); Immune Modulator Mix (a combination of vitamin, minerals, antioxidants and immune-enhancing natural products); nitrogenated soy extract (high levels of genistein and dadzein) and Andrographis Paniculata (500 mg twice, daily) were used. Baseline NK function by standard 4 h 51Cr release assay and TNF alpha and receptor levels were measured by ELISA from resting and phytohemagglutinin (PHA) stimulated adherent and non-adherent Peripheral Blood Mononuclear Cell (PBMC). Total mercaptans and glutathione in plasma were taken and compared to levels measured 6 months later. Complete blood counts and chemistry panels were routinely monitored. As of a mean of 6 months, 16/20 patients were still alive. The 16 survivors had significantly higher NK function than baseline (p < .01 for each) and TNF-alpha levels in all four cell populations studied (p < .01 for each). Total mercaptans (p < .01) and TNF-alpha receptor levels were significantly reduced (p < .01). It was also observed that hemoglobin, hematocrit and glutathione levels were significantly elevated. The only toxicity noted was occasional diarrhea and nausea. The quality of life improved for all survivors by SF-36 form evaluation. An aggressive combination of immunoactive Nutraceuticals was effective in significantly increasing NK function, other immune parameters and hemoglobin from PBMC or plasma in patients with late stage cancers. Nutraceutical combinations may be effective in late stage cancers. Clinical outcomes evaluations are ongoing.
INCREASED TUMOR NECROSIS FACTOR ALPHA AND NK CELL FUNCTION | |||||
PATIENT DEMOGRAPHICS | PATIENT REGIME INCLUDED | RESULTS AFTER SIX MONTHS | |||
Twenty patients | Enhanced Transfer Factors, Beta Glucans, soy | Average Tumor Necrosis Factor alpha | |||
4Life Transfer Factor® Products Approved for Use by Olympic Athletes
Salt Lake City, Utah (December 4, 2007) As first reported by 4Life Chief Scientific Officer Calvin McCausland, Ph.D., in Direct Selling News, 4Life received documentation from the Federal Anti-Doping Center in Moscow, Russia, that admits 4Life Transfer Factor for use by Olympians in practice, training, and competition. Approval was obtained after volunteers consumed 4Life Transfer Factor products and their bodily fluids were analyzed in accordance with doping control procedures that employ modern methods of gas chromatography and mass-spectrometry in compliance with the World Anti-Doping Agency in Montreal, Canada.
“We are very pleased by this approval,” commented President of Eurasia Emma Oganova, M.D., Ph.D. “4Life Transfer Factor continues to define the cutting-edge of immune system science.”
4Life Founder and Chief Executive Officer David Lisonbee launched 4Life Research in 1998 with a commitment to the highest scientific standards. Ongoing research and development of Transfer Factor technology has fueled 4Life’s constant growth and maximized every distributor’s ability to grow a successful independent business.
“Arguably, this kind of marketplace positioning and high level product messaging simply isn’t possible without the involvement of a professional research and development team,” added McCausland.
“I am pleased with our continued evolution in the supplement industry,” stated Executive Vice President Bruce Redd. “The quality work of our Research and Development department is certain to keep 4Life on the leading edge of science and success for years to come.”
4Life, the leader in the development, production, and distribution of Transfer Factor support products, continues to post growth in more than 40 countries around the world.
Mark Todd and his horse, Gandalf
Salt Lake City, Utah (June 19, 2008) 4Life Research™ announced today that Mark Todd, famed New Zealand equestrian, will publicly endorse 4Life products.
Todd was voted Rider of the 20th century by the International Equestrian Federation. He is a four-time Olympic medalist, including two gold medals. He primarily competes in eventing, which includes dressage, cross-country, and show jumping. In 1984 and 1988, he was the first rider to win successive individual three-day-event Olympic gold medals in 60 years. He won the prestigious Badminton Horse Trials on three occasions and the Burghley three-day trials five times.
He retired from eventing following the 2000 Sydney Olympics, but decided to make a return for the 2008 Beijing Olympics. In May 2008 he qualified for the 2008 Olympics at the three-day event in Samur, France.
“I am 52 years old and competing in my fifth Olympics,” remarked Todd. “I use 4Life Transfer Factor Plus® to help keep me at the top of my game. It provides the well-being and healthy energy support I need to continue at top-level competition.”
“I’m very excited to have Mark Todd endorse 4Life products,” commented Vice President, International Jason Norton. “As an accomplished equestrian in New Zealand, his endorsement speaks volumes to distributors and new recruits about the quality of our products. This is exciting news for 4Life markets around the world.”
“I’m thrilled about Todd’s endorsement agreement,” remarked Managing Director of 4Life Australia and New Zealand Ben Riley. “He understands the importance that nutrition and supplementation play in maintaining wellness, and uses 4Life Products to help him perform his best.”
4Life, the leader in the development, production, and distribution of Transfer Factor support products, continues to post growth in more than 40 countries around the world.
Salt Lake City, Utah (January 18, 2011) 4Life executives are pleased to announce that 4Life Transfer Factor® products are listed in the 2011 Physician’s Desk Reference (PDR)
“We are thrilled to be part of this prestigious and valuable publication,” stated Chad Renshaw, Director of Product Development. “The PDR is among the most substantiated resources and is distributed to 470,000 health professionals in the United States. Having 4Life products listed in the PDR provides distributors with unrivaled credibility when presenting our products to customers.”
The 2011 edition of the PDR provides in-depth product information about 4Life Transfer Factor® and 4Life® Transfer Factor Plus® Tri-Factor® Formulas. In addition, the publication offers a technical description of the product line and synopses on several clinical studies.
Brent Vaughan, 4Life Director of Health Information Systems: “This professional listing gives 4Life Transfer Factor an additional boost in the scientific community, and helps strengthen every distributor’s position as an exclusive leader in the distribution of Transfer Factor products.”
4Life has offices on five continents to service a global network of independent distributors through science, success, and service.
“Most products on the market today provide nutrition to the immune system. What the immune system really needs—and what 4Life Transfer Factor provides—is information. 4Life Transfer Factor gives your immune system the information it needs to recognize, respond to, and remember potential invaders.”
- Dr Calvin W. McCausland, PhD, Chief Scientific Officer, 4Life Research
In 1966, Calvin McCausland received his Bachelor Degree in Chemistry from Brigham Young University. Less than a year into his Doctoral program, he was drafted into the US Air Force and served as a Meteorologist, attaining the rank of Captain. He began working in industry as a research and development chemist while completing his Doctorate in Organic Chemistry in 1974.
When his wife succumbed to cancer, Dr McCausland became convinced that prevention was better than any therapy. This led him to employment in 1982 as Director of R&D for a dietary supplement company. Responsible for new product development, he supervised the creation and reformulation of over 350 health supplements. Many of these still remain top sellers for the company.
In 1986, at the invitation of the Chinese government, he travelled to China and Tibet to investigate traditional medical practices using plant and animal products.
Dr McCausland established Enhanced Living International in 1989, where, as Chief Scientific Officer, he created an innovative line of science-based health supplements including the first multiple vitamin C product, the first gender specific supplements and products for cardiovascular health, athletic performance and others.
A need to support the newly opened Russian market saw a new chapter open for Dr McCausland in that country. He became the inaugural President of the non-profit Center of Micronutrientology in Moscow in 1997. There he developed an academy, establishing a new curriculum of complementary medicine and nutrition. Within two years, the Center’s diploma in Micronutrientology won federal approval.
Dr McCausland became, in 1997, the first American ever to be elected a Member and Academician of the Russian Academy of Medical and Technical Science, the nation’s most prestigious recognition in science. In 1998 and 1999, he organised nine clinical studies of nutritional supplements in hospitals, clinics and National Institutes.
In 1999, he received the Kosygin Award, in recognition of the most significant contribution in science and medicine to impact on the future economy of Russia. In 2000, the Academy bestowed upon Dr McCausland its Pokrovsky Award for scientific originality.
Having lectured in nutrition and micronutrientology in the USA, Canada, Russia, Japan, Malaysia, Australia, New Zealand, Mexico, Thailand, Philippines, Ukraine, Kazakhstan and participating in many international scientific conferences, Dr McCausland has visited more than 70 countries.
Joining 4Life Research in September 2000, he said “science has started to confirm what those in nutritional circles have long known. It is exciting to see that this vital but long-overlooked area of study is finally getting the validation it so rightfully deserves. 4Life has proven itself to be a company that provides sound dietary supplements, in keeping with the latest research. This commitment to providing revolutionary natural products is one that I am excited to help develop. I am particularly struck with the potential that exists for Transfer Factors. Transfer Factors are today where vitamins and herbs were 15 years ago.
Independent Bio-Assay Overview December 11, 1998
Salt Lake City, UT – 4Life Research, a Provo, Utah research and development company released its latest assaying and testing for its new 4Life Transfer Factor™ product.
Transfer Factor is a scientifically recognized delivery system for transferring immune system advantages from one species to another. In the patented process licensed to 4Life, immune factors are generated in cows and then “transferred” as a nutritional supplement to humans. Products manufactured incorporating the process are anticipated by industry experts to be the “next wave” of nutritional supplementation, operating in the newly defined area of “structure/function” claims. Dr. William Hennen, who is one of the world authorities on Transfer Factor, says of the science and technology:
“Transfer Factor is a material that has the ability to modulate the immune system. 4Life Transfer Factor™ contains both materials that help the immune system respond more effectively and materials to make sure the immune system is not over-responding.”
4Life’s founder and president, David Lisonbee said, “4Life has an agreement with the patent inventors to market Transfer Factor. United States Patent No. 4,816,563, issued on March 28, 1989, is licensed to 4Life. This patent describes the proprietary process used by 4Life to create its unique Transfer Factor™.
The only patent 4Life is aware of which identifies Transfer Factor in colostrum, the process for obtaining transfer factor from colostrum and whey, and the patented method “to further concentrate and/or purify Transfer Factor” from colostrum, is the one licensed to 4Life. It is United States Patent No. 4,816,563.
Laboratory Testing of 4Life’s Transfer Factor™ According to William Hennen, Ph.D., Vice President of Research and Development at 4Life, “Each and every batch of Transfer Factor™ is tested by an independent laboratory with established, documented credentials in assessing for Transfer Factor activity. Very few laboratories have the experience or credentials to assay for TF activity. We go to great lengths to assure the quality of Transfer Factor in our product. This is the reason our distributors are consistently having such great success with Transfer Factor™ . From infants to the elderly, reports keep coming in every day with results that have matched or exceeded our every expectation. Transfer Factor has nearly 50 years of research and over 3,000 clinical studies and scientific papers proving its existence and effectiveness. Our licensed patent proved for the first time that Transfer Factor exists in colostrum and that it can be successfully extracted and assayed.”
Independent Laboratories Show Transfer Factor Activity in 4Life’s Transfer Factor™ Independent laboratory tests clearly indicate that 4Life’s Transfer Factor™ shows significant Transfer Factor activity equal to the effectiveness of the standard vaccine. The biological and chemical testing laboratory, BioLogics Inc. states the following regarding 4Life’s Transfer Factor™
“Further, it is critical to understand that a proper Transfer Factor assay includes both a zero-point standard and a high-end standard (to set the span of the scale.) The zero-point standard accounts for the nutritional value of the Transfer Factor preparation and is represented by the fractionated colostrum listed in the second row above. A vaccinated control is the GOLD STANDARD for establishing the high-end of the immunological scale as represented in the first row. As was clearly shown, 4Life’s Transfer Factor™ was not only measurably more potent than the normal colostrum of the second row, it was equal to the vaccine standard in causing a strong immune response,” stated Dr. Hennen.
Top Transfer Factor Researcher Tests 4Life’s Transfer Factor™. One of the world’s leading TF researchers has also tested 4Life’s Transfer Factor™ using a mouse foot-pad assay. “Three different colostrum extracts were tested, one of which was 4Life’s Transfer Factor™. 4Life’s Transfer Factor™ tested highest in TF activity of any of the samples tested.”
Molecular Weight Laboratory Testing of 4Life’s Transfer Factor™ An independent laboratory experienced in molecular weight analysis tested samples of 4Life’s Transfer Factor™ and found it to contain exactly what 4Life claims it contains: Molecules in the molecular weight of 10,000 daltons or less. Bay Bioanalytical Laboratory, Inc. stated in their report: “[We] have reviewed the analysis of [4Life's] Transfer Factor performed in our laboratory using HPLC and a size exclusion column coupled with a light scattering, refractive index and a UV detector. Based on our analysis we can conclude [that] the analyzed fraction is composed primarily of molecules below 10,000 [daltons] molecular weight.” Bay Bioanalytical Laboratory, Inc.
Quality. What does it mean to you? To 4Life™, it means providing the best health and wellness products available in the world today. Products made with the finest, scientifically researched ingredients and proven for their effectiveness. For you, it means receiving the health support you need from supplements that you can count on for consistency and guaranteed potency each time you use them. 4Life has developed an unsurpassed quality assurance process hallmarked by stringent attention to detail. Our dedication to quality begins at the very first stages and continues throughout the entire process of product development. From growing or manufacturing the ingredients to packaging, labeling, storage and distribution, the highest standards of excellence are continually aimed for and achieved. With all of the products 4Life™ has to offer, you can be assured that only the finest, guaranteed potency ingredients are used and scientifically blended. Patented ingredients and proprietary extract blends are also utilized in each line, adding the power of synergy and uniqueness to our products. 4Life™ further ensures quality by always striving to stay on the cutting-edge of research and development. This is accomplished by utilizing a Medical Advisory Board that includes a group of some of the country's leading physicians, immunity experts, nutritionists and formulators, all of whom use the 4Life™ products in their personal lives and practices every day. These practicing, professionals work to further efforts in research and product development, and provide a constant influx of new information and awareness regarding current health issues. How confident are we in our ability to provide our distributors and customers with quality products? Enough to back every one of our products with a 100 percent, 30-day, money-back guarantee. These key elements describe why 4Life™ continues to lead the industry in product quality and consumer confidence. With your health and happiness in mind, 4Life™ promises that premium product quality and our commitment to complete and optimum health will be foremost in all of our corporate decisions. We fully believe that, with consistent focus on these sound principles, 4Life™ has and will continue to offer the best opportunity and products to people around the world.
Founder David Lisonbee’s history of health problems was about as long as his network marketing career, which started in the 1970s. So even after he retired, he kept looking for something that would help. And he found it. David had developed some 300 nutritional products during his career, and research was in his blood, even when it came to his own health. He became convinced that the key to health went beyond vitamins, minerals and essential amino acids. His search led him to a substance called Transfer Factor, which is found in the body’s immune system. It became his eureka! He learned that Transfer Factor was first discovered in 1949. Essentially, it is a communication module in the first milk of mammals—such as cows and humans—that transfers immunity from a mother to her offspring. A 1989 patent had been filed for a process that extracted the molecules from cow’s milk. Several hundred studies had been done on Transfer Factor. Intrigued, David contacted the two University of South Carolina professors who held the patent and struck a deal to use it to develop products that support the immune system. “I thought it could have such a significant impact on people’s lives,” he says. And to him it made sense that products using Transfer Factor should be marketed through a direct selling company. But then he faced the toughest sale of his life: his wife, Bianca.
Recently, we reported the initial results of a groundbreaking independent study using Transfer Factor and Transfer Factor Plus. Both yielded unprecedented results in a study done by the Institute of Longevity Medicine in California, a laboratory recognized for its research and expertise in measuring the ability of ingredients to significantly boost the immune system. Transfer Factor and Transfer Factor Plus were tested for their ability to increase Natural Killer Cell (NK) activity. The researchers used peripheral blood mononuclear cells (PBMC) isolated from human volunteers. Test results showed that Transfer Factor boosted NK cell activity 103% above normal immune response without supplementation, more than two times higher than the next highest product. The study also showed that Transfer Factor Plus increased the NK cell activity 248% above normal immune response without supplementation, or about five times higher than any of the other previously tested products. Natural Killer Cells are an important part of our body's immune system. They seek and destroy harmful cells through direct contact. Natural Killer Cells are especially important in strengthening and supporting the immune system. David Lisonbee, CEO of 4Life Research, in response to this research said, "These recent findings support and substantiate the reports from thousands of distributors who use Transfer Factor and Transfer Factor Plus. The study also supports many other clinical experiences and studies we are familiar with. We are very pleased with the study results, they come as no surprise to us."
The abilities we have to protect ourselves are both instinctive and learned. Our instinctive responses are untrained and are our first defensive responses to an outside threat. The strength of our instinctive response oftentimes determines its effectiveness in getting us out of danger. The better our hearing, vision, and agility, the better we are able to recognize and dodge threats that may suddenly appear in our environment. Just like our instinctive responses to physical threats, our innate immune responses are part of our instinctive response to microbial threats. The immune system has various response capabilities. Certain of these responses are instinctive and are part of what is called the innate response. These instinctive responses exist naturally without prior training. The extent of the response, however, varies according to the conditioning of the system. A better-conditioned system produces a stronger response to a given stimulus. If this innate, instinctive, and first-line immune defense is adequate no additional response is necessary. Within the immune system certain fungal factors and other glyconutrients condition the system and increase its innate responsiveness. Cordyvant™ is a balanced, proprietary blend of glyconutrients designed to enhance the innate immune response and strengthen of our first-line defensive response. If our innate ability to physically defend ourselves is inadequate, then we must learn additional skills such as boxing, Judo or Karate. Similarly, our innate immune ability may be inadequate against the microbial mob. In these cases our immune system has the ability to learn new skills. A strong immune system has the ability to invent new techniques to deal with each new challenge. This is called the adaptive or learned response of the immune system.
Global Record Sales After 12 Years of Growth
Salt Lake City, Utah (April 7, 2010) 4Life Research has announced that worldwide sales are up 45% for the month of March 2010, from the company’s record-breaking growth of 2009.4Life President Steve Tew: “In the face of a global recession, 4Life distributors around the world have refused to allow sobering financial trends to limit their success. From the Far East to Europe and South America, 4Life markets continue to post record-breaking sales.”
David and Bianca Lisonbee launched 4Life in 1998 with Transfer Factor Classic®. Over the last 12 years, 4Life Research has established itself as a world leader in the areas of science, success, and service. 4Life is a proud member of the Direct Selling Association (DSA) in the United States along with more than a half dozen DSA affiliates around the world.
4Life Year-Over-Year Growth
United States: 40%
Mexico: 20%
Colombia: 22%
South Korea: 31%
Philippines: 40%
Singapore: 48%
India: 51%
Hong Kong: 61%
Spain: 61%
Eurasia: 62%
Europe: 86%
Malaysia: 90%
David Lisonbee, 4Life Founder and CEO: “One of our missions has always been, Taking Transfer Factor to the World. After twelve years, I can say with confidence that thanks to our 4Life distributors, we have. Moving forward, we’ll continue to support business builders with the best products and compensation in the industry and together serve those who require our assistance.”
4Life has offices on five continents to service a global network of independent distributors through science, success, and service.
4Life Research rated Top 10 MLM companies in the book "The Best Companies in Network Marketing: 2005-2006"
"What an estimable honor," says David Lisonbee, 4Life Founder and CEO. "In our industry, it's one of those moments that a company builds toward. It's a great tribute to receive the recommendation of distributors in the field and we look forward to excelling our efforts throughout 2006."
4Life's Life Rewards Plan is as unique an opportunity as 4Life Transfer Factor is a product. Based on the principles of helping, sharing, identifying and fulfilling needs - 4Life® builds people financially with one of the most lucrative compensation plans in the industry. But Life Rewards isn't merely pay. It's about developing relationships and strengthening family ties. 4Life's Life Rewards is about money and so much more than money.
Bianca Lisonbee, 4Life Co-Founder, responds to the Distributors Choice Awards: "It's really inspiring to see the culture of Distributors that 4Life is attracting. They are a group of people who believe in building others. This recognition is both humbling and invigorating."
"We really enjoy the friendships and relationships that we have with our 4Life Distributors. There's no greater satisfaction than watching others succeed and supporting that growth," David Lisonbee concludes.
SANDY, UT (June 25, 2004) In two separate papers published in the February issue of The Journal of Immunology, Christian Munz, Ph.D. and Guido Ferlazzo, Ph.D. of Rockefeller University discovered that natural killer cells in the body need to acquire the ability to recognize and destroy infected cells and “…have to be nurtured. Their ability to destroy tumor and infected cells is not present at birth.?
Munz and Ferlazzo are also beginning to understand that natural killer cell function can be “tailored?or “targeted?toward specific healthy immune support activity.
Significance of this Announcement for 4Life commenting on this discovery, David Lisonbee, CEO of 4Life stated, “This is a significant discovery that validates what 4Life has been teaching for the past six years. 4Life?Transfer Factor? is effective because it gives the natural killer cells the information necessary to recognize harmful cells that are attacking the body. Since natural killer cells need to be nurtured or tutored and are not born with the knowledge of which cells are harmful, it is easy to see why 4Life Transfer Factor is enjoying the tremendous success and recognition that it has received.
Targeted Abilities of 4Life Transfer Factor, Mr. Lisonbee went on to say, “It was very interesting to me that Munz and Ferlazzo have identified a need to start targeting natural killer cell function to attack specific diseases or infection. This has been the vision behind the targeted line of 4Life Transfer Factor products. We are now targeting healthy heart function, brain function and healthy glucose levels because of their relationship to inflammation and infection. The reports we have received from doctors and customers have exceeded our expectations.
Head and Shoulders above Other Immune Support Products
“Our original line of 4Life Transfer Factor products was proven to be 10 to 20 times more effective than products such as echinacea or whole cow colostrum. Our new 4Life Transfer Factor Plus Advanced Formula is almost twice as effective as the former 4Life Transfer Factor Plus product. The remarkable new 4Life Transfer Factor products will put 4Life head and shoulders above other immune support products and give our distributors a tremendous advantage in the market, concluded Mr. Lisonbee.
Gynecologic Oncologist Objective:
Our medical practice has been collecting data for the past year for a variety of gynecologic conditions to determine what 4Life Research™ products could do for our patients. Each trial was observed for at least two months and most are ongoing.
- Conditions:Fibromyalgia, Arthritis, CFS 57 patients, primarily women ages: 40 – 50
- Dosage/Protocol: Fibro Free Protocol Phases 1-3
- Results: 55 have had major improvement (4 – 6 weeks time response)
- Condition: Menopausal symptoms 81 women – ages: 42 – 75
- Dosage: usually one BioGenistein Plus™ and apply FemRite™ twice daily. 21 had mild hot flashes requiring some estrogen 15 required daily estrogen doses (time response varied)
- Results: 45 exhibited no symptoms of disease.
- Other gynecologic problems: ages: women 25 – 50 years
- Dosage: usually one BioGenistein Plus™ and apply FemRite™ twice daily
- Results: 7 women with fibroid tumors: in six, the tumors are shrinking (3 – 4 months time response) 35 women with PMS
- Results: symptoms controlled in 33 women (4 week time response) 32 women with abnormal uterine bleeding
- Results: 26 returned to normal (some had results immediately, others saw results by 4 – 6 weeks)
- Transfer Factor used with over 300 individuals.
- Conditions: Cancer, herpes, yeast, condyloma, arthritis, colds, sore throats, and lupus. Ages: 2 – 80 years
- Dosage: maintenance – 3 TF daily Illness – triple daily dose
- Results: all have noticed dramatic improvement [time response varied according to seriousness of condition (most serious - 4 weeks or more)
http://www.healingdaily.com/conditions/colostrum.htm A basic overview of why colostrum carries molecules that transfers immunity.
Cancer Cells
“Transfer Factors are small proteins that “transfer” the ability to express cell-mediated immunity from immune donors to non-immune recipients.” Molecular Medicine, April 6, 2000. One of the members of fasting.ws send me her personal experience with using “Transfer Factor” that produces a product based on Colostrum. After looking at both the pros and cons I feel this is an excellent product that would work in synergy with juice fasting as a treatment for many immune system diseases. There is a substantial body of anecdotal evidence on the Internet with many long term users of colostrum products claiming many benefits to health. A Transfer Factor is a stellar polypeptide which was discovered around 59 years ago. There are scores of studies on Transfer Factor and its ability to boost immune function. Countless trials describe how it has been used for a whole host of problems which involve the immune system.
Transfer Factors can now be extracted from cow colostrum, concentrated and offered in supplement form. These molecules are not species-specific making them cross-species compatible. While different mammals may have a unique colostrum mix, the Transfer Factors contained within their colostrum are the same. Transfer Factors produced by a cow can work just as effectively in humans as they do in animals. The ability to receive immune data that is transferred from the cow to the human has the potential to revolutionize the way we look at disease prevention in medicine.
First your immune system is strengthened so that when new viruses or bacteria invade your body, your heightened immune cells react very rapidly. By so doing, they prevent the foreign organism from getting a toe hold; consequently, even if you do get sick, the infection will be milder.
Secondly, when you take Transfer Factor, you store these borrowed messenger molecules in your own immune data banks. As a result, when you are invaded by an organism that had previously infected the cow, the acquired Transfer Factor molecules stimulate you immune system to specifically recognized and react to this particular microorganism.
Third, if your immune system is over-reactive (something seen in autoimmune diseases like arthritis, lupus, etc.) Transfer Factor will modulate or calm immune defenses which inadvertently attack healthy tissue thereby improving one’s health.
Transfer Factors are a Modifier of Biological Age
A.G. Chizhov, V.A. Santalova
Russian People’s Friendship University, Moscow
There is a close link between the decrease of functional activity of the immune system and aging. Thus, we decided to study immunomodulators to determine to what extent they may affect biological age indices. A new immune theory of aging (V.I.Dontsov, V.N. Krut’ko, 2002) points to the role of specific T-lymphocytes subpopulations in sustaining a certain level of normal cellular growth in the body and dwells on the importance of their functional decrease having a strong impact on aging. Stimulation of the function of these cells by Transfer Factors, an immunomodulator, seemed a plausible method of “treating aging”. The evaluation of the role transfer factors contribute in the process of aging is at the basis of this study.
Twelve (12) men aged 55-73 were included in the study. A dose of 300 mg. of Transfer Factors was given daily with meals 5 times a week for 6 weeks.Biological age was determined using the “АPK” method (“Diagnostics of aging: biological age” (National gerontology center, Moscow). The following biomarkers were used for making the determinations: AP (arterial pressure), pulse wave velocity, VC (vital pulmonary capacity), static balance, Shtange’s test, adaptation testing, body mass, left hand strength, Shulte’s test, Veksler’s test, neuromuscular test, hearing frequency threshold and the SAN’s questionnaire. The functional activities of body systems were evaluated by means of Nakatani’s electropuncture diagnostics. Chronological age of the group was 63.5±0.7. Before the use of Transfer Factors the biological age of the group differed from chronological by -4.2 ±0.6 years. The majority of men demonstrated a decrease in the functional activity of endocrine and of immune systems’ as well as hyperfunction of the liver and of urinary bladder and hypofunction pancreatic.
Results: The study showed that initially disturbed body system functions were significantly normalized. After the course of Transfer Factors treatment, the difference between biological and chronological age was (-8.2) ± 0.5 years (p0.05), which is a rejuvenation effect of 4 years.
Authors: Giancarlo Pizza (1), Caterina De Vinci (1), Aldopaolo Palareti (2), Dimitri Viza (3).
Institution: (1) Immunotherapy Unit, 1st Division Of Urology, S.Orsola- Malpigi Hospital Bologna, Italy; (2) Department Of Computer Sciences, University Of Bologna, Bologna, Italy; (3) Laboratoire D´Immunobiologie, Faculté De Médicine Des Saints-Péres, Paris, France.
Abstracts:
Patients. From April 1974 to January 1999, using products contianing transfer factors in our laboratories, we treated a total of 1647 patients (pts) suffering from persistent viral infections viz. hepatitis, herpes, herpes zoster, giant condyloma acuminatum, conjunctivitis, herpes keratitis and keratouveitis, (439 pts), cancer, viz. Prostate, lung, renal metastatic, transitional cell carcinoma of the bladder (TCCB), EBV-related naso-pharyngeal carcinoma (NPC), gastro-intestinal (GIT), ovary, uterus, Burkitt´s lymphoma, breast, glioblastoma (643 pts), recurrent cystitis and candidiasis (287 pts), chronic fatigue syndrome (74pts.), AIDS (51 pts) and/or various congenital and(/or autoimmune disorders, e.g. retinitis pígmentosa, chorioretinitis, uveitis, Bechcet´s syndrome and Lapeyronie´s disease (153 pts).
Methods. Transfer factors were extracted from buffy-coats of blood donors or produced in vitro using lymphoblastoid cell lines and, in this case, it was specific for one of the following: HSV, hepatitis B virus, candida albicans, HPV, HHV-6, varicella-zoster, HIV. In most cases, Products utilizing transfer factors were the only treatment. However in several cancer and SIDS patients it was included, in a strategy of immune-modulation, as an adjuvant of chemotherapy (Burkitt´s lymphoma), surgery and radiotherapy (NPC, lung carcicoma, GIT, ovary, uterus, breast, breast, glioblastoma), hormone therapy (metastatic carcinima, GIT, ovary, uterus, breast, glioblastoma), hormone therapy (metastatic prostate cancer), trans-urethral resection and complement-fixing anti-tumour antibodies, interlukin-2 (IL-2)a nd interferon-alpha-2ª (a-IFN) instillation in the urinary bladder for the immunoprophalaxis of TCCB, IL-2 and a_IFN for metastatic renal cancer, and antiretroviral therapy for AIDS. The duration of the treatment ranged from 6 to 127 months. products containing transfer factors were administered i.m. or orally. In 279 patients with recurrent ocular disease (139 herpes keratitis, 47 kerato-uveitis, and 93 uveitis) HSV-specific products with transfer factors were orally administered for at least 3 months with a mean duration of 687 days, whereas the entire follow-up period was 365913 before and 191772 days after the transfer factors treatment.
Conclusion. In 1/3 of the patients the observation period exceeds 20 years. Thus the results confirm not only that specific Transfer Factors treatment is effective in several pathologies, and it lacks acute but also chronic toxicity. Indeed, side effects were never observed in any of our patients thus corroborating the already established consensus of the complete safety of Transfer Factors administration.
· Cancer
· AIDS
· HIV
· Lupus
· Common Cold
· Flu
· Parkinson's
· Arthritis
· Multiple Sclerosis
· Alzheimer's
· Lou Gerhig's Disease.
Products utilizing Transfer Factors is the result of 5 decades of research and testing. It works by successfully transferring antigen-specific agents from a donor to a host. In simple terms one person's immune response to a certain disease could be precisely duplicated so that another person who had little or no immune response to the same agent could likewise fight off an infectious agent like Streptococcus or Diphtheria.
· Elevates the body's own immune system to specific antigens
· Transfers distinct cell-mediated immunity to a deficient recipient
· Remarkable treatment results have been seen for viral fungal and parasitic infections including HIV and AIDS Epstein-Barr virus Herpes Multiple Sclerosis Alzheimer's Disease Autism ALS (Lou Gerhig's Disease) and Chronic Fatigue Syndrome
· No known side effects; Non-toxic
Essentially transfer factors are an immunotherapy which transfers distinct cell-mediated immunity from an immuno-sufficient donor to a deficient recipient. The results of this treatment are consistent and remarkable for viral fungal and parasitic infections alike...all without side effects and toxicity. Through transfer factors targeted immunotherapy treatment is now possible for patients suffering from serious infections that were once thought to be untreatable.
Beta Source is the only company in the world that:
· The only company that owns the only U.S. patent to derive transfer factors from colostrum.
· Has the proven capabilities to commercially produce and manufacture Antigen Specific Transfer Factors derived from colostrum.
· Is properly licensed as a business for the manufacture and sale of transfer factors.
· Is solely dedicated to the manufacture of transfer factors and other immune modulating products
· Provides quality controls for all transfer factors.
· Guarantees presence of transfer factors activity and potency product safety and absence of antibiotics.
· Guarantees absence of microbes such as E. Coli Salmonella and other bacterial coliforms.
That discovery over 25 years ago is viewed today as one of the remarkable elements in transfer factors effectiveness. Transfer factors acts as a "tailored" treatment by communicating the exact immunological information from the donor to the recipient regarding a single or as many as thousands of specific antigens.
In 1970 Dr Hugh Fudenberg et al began using transfer factors as treatment on patients suffering from Wiscott-Aldrich Syndrome. His scope later widened to include candidiasis (yeast infection) several viral type cancers as well as fungal and parasitic diseases (reviewed in reference 6).
Research efforts subsided somewhat during the 1970's largely due to the high price tag coupled with a focus on mostly rare viruses. Even so immunologists remained very interested in transfer factors potential and research slowly but surely moved forward.
Over the next decade there were continuing revelations about the nature and targeted effectiveness of transfer factors. For example tests were conducted in 1981 by Dr Kahn et al (7) in seventeen patients with herpes who were given injections containing transfer factors at intervals of one week to 3 months with noteworthy results. Sixteen of the seventeen patients involved in the study showed definite decreases in recurrence with eight of those treated being completely free of the disease. T-cell function improved significantly and it was likewise noted that transfer factors induced interferon (production) increase.
A 29 year old woman with a long history of low immune resistance contracted both generalized herpes zoster and varicella pneumonia in 1985. Her condition was described as "desperate" due to respiratory failure and an overall degrading chest condition. She responded quickly after treatment with transfer factors from a healing herpes donor (8). Once again this case points to ability of transfer factors to effectively target specific antigens.
The Epstein-Barr virus in combination with a cytomegalovirus (CMV) infection was treated in a four year old child who had suffered for two years with recurring fevers rashes abdominal pain and other nagging symptoms (9). He was then given products containing transfer factors by mouth. Incredibly his symptoms disappeared and the child even developed a specific CMV immunity.
Additional case studies revealed transfer factors effectiveness in treating candidiasis cryptosporosis and Burkitt's lymphoma (10-13). Even as the general public was only beginning to hear terms like HIV and AIDS in the 1980's transfer factors treatment attempts had begun for HIV patients suffering from severe viral diarrhea (14). Of the seven patients treated with transfer factors six patients gained weight and showed a decrease in bowel movement frequency. Other AIDS cases resulted in partial immune system enhancement when treated with transfer factor.
Today in the final decade of this century studies involving transfer factors are consistently showing up worldwide. Several including those from the National Academy of Science of the United States of America (15) have focused on the transmission relationship between an HIV type I infected mother and her unborn child. Generally when the mother's viral load is decreased so is the likelihood of HIV-I being transmitted to the baby. This was observed in 1995 from a group of thirty HIV I pregnant women.
Eight of the ten women with the highest levels of HIV-I RNA (above 50 000 copies per milliliter) transmitted the disease at delivery while none of the twenty women with lower levels (below 20 000 HIV-I RNA copies per milliliter) passed HIV-I on to their children.
Dr. H. Hugh Fudenberg M.D. has greatly broadened research and treatment efforts using transfer factors. To date he is the only one to have successfully treated subsets of Alzheimer's Disease Autism Chronic Fatigue Syndrome and subsets of ALS (Louhig’s Disease). Similar work by others points to Myasthenia Gravis and Multiple Sclerosis as having an immunological base which can be altered or reversed through large amounts of transfer factors(6 16 17).
Infected patients who are tracked up to ten years show positive residual effects from transfer factors.(6). A large number of peer-reviewed scientific papers testified to these facts as well as transfer factors consistent track record of partially or completely reversing specific viral infections. Immunological researchers continue to explore new treatment applications for transfer factors(6).
President Obama Addresses The American Medical Association Annual Meeting
Well recognized organizations such as The Associations of American Physicians American Society for Clinical Investigation and the American Federation for Clinical Research recently published the following in a paper presented at the Biomedicine Conference in early May 1996:
"Antigen specific transfer factor is often shown to be highly effective in viral infections unresponsive to prescription medications; and preliminary studies with AIDS patients and HIV-infected macaques have produced encouraging results (18)."
It is clear that transfer factors have many advantages – most notably is its ability to precisely mirror the immune sufficiency of the donor. Yet there remains the proverbial question of economics. Thus far transfer factors have been extremely expensive to research and produce even in very small quantities. It would take a fully staffed laboratory of MD's PhD's and technicians dedicated exclusively to production of transfer factors to make even a small quantity of usable material. The cost per dose would exclude all but the wealthiest people from receiving transfer factors treatment.
Currently due to the generosity of the French government Dr Dimitri Viza in Paris has produced products that contain transfer factors and distributed it to people in various parts of the world. Yet to secure even a small amount thousands of dollars must be paid in advance. This scenario has greatly limited efforts toward mass production of these products until very recently. Fortunately the problems of mass production and administering proper dosages have been addressed and successfully overcome by Dr's Greg Wilson and Gary Paddock (19-23). Their technology now allows transfer factors to be successfully developed using a non-human source. Through strictly controlled replication techniques the "tailored" transfer factors are mass produced which in turn greatly reduces the cost of raw materials by as much as twenty times. Thanks to this new process dosages that contain transfer factors are in the same price range as high-priced antibiotics.
Immuno-deficient patients no longer need to carry the heavy financial burden of other treatment options (i.e. antiviral cocktails and combo therapies) nor must they endure the toxic side effects and their associated additional costs. Transfer factors in treatment is non toxic and non-addictive regardless of dosage amounts.
In the past there has been concern about properly regulating dosages. Those concerns have likewise been put to rest with recent developments in therapy involving transfer factors. Based on the doctor's assessment a therapeutic or prophylactic regimen is established for the patient which is then easily and routinely monitored via appropriate interval testing (20).
Many physicians and other medical experts are voicing the same conclusions about combating infectious diseases - conventional pharmacology is not winning the war. In fact it is estimated that by the year 2030 currently known drugs will be helpless in fighting bacterial infection (24).
Therein lies the critical importance of transfer factors. By elevating the body's own miraculous immune response to specific antigens patients and doctors alike can potentially reach their mutual goal which is effective treatment of the patient's viral illness and the hope of success.
Today people suffering from common bacterial infections are often administered antibiotics to augment the body's own reservoir of antibodies. The story changes however with serious virus infections such as Epstein-Barr virus cytomegalovirus cryptosporosis Hrpes simplex types 1 and 2 HIV and others. In such cases patients have literally been overwhelmed by invading antigens and have lost much of their body's miraculous ability to fight infection. What is required is an "outside source" that both possesses and can transmit the precise antigen-fighting ability necessary for the recipient to once again fight the viral infection on their own. Transfer factors have been intensely researched and documented since its discovery in 1949 by Dr HS Lawrence. Essentially transfer factors are an immunotherapy which transfers distinct cell-mediated immunity from an immuno-sufficient donor to a deficient recipient. Results of this treatment are consistent and remarkable for viral fungal and parasitic infections alike all without side effects and toxicity (6).
The Human Body - A Marvelous Creation
Experts say that our bodies house one trillion immune cells rendering the capability to recognize and deactivate ten million different antigens (invading viruses bacteria fungi parasites etc.). However each of us can be missing as many as 50 000 specific antigen responses which makes us susceptible to those invaders.
Our immune system features a blend of five components working in harmony to fight infection. These "defenders" include stem cells B-lymphocytes natural killer cells macrophages and in command of the whole process T-lymphocytes. It is through this combination that invading antigens are identified targeted surrounded attacked and destroyed.
Transfer factors are a substance within our immune cells specifically T-lymphocytes that imparts the "blueprints" of individual antigens. These "blueprints" or memories enable T-lymphocytes to immediately recognize an enemy antigen.
1.Stem cells are best regarded as maturing cells that will later develop into one of the other four cell types.
2.Secondly B-lymphocytes are responsible for producing antibodies that will later recognize and attach themselves to a specific invader.
3. Once the invading antigen is marked for destruction by the B-cell antibody the natural killer (NK) cells carry out the antigen's demise.
4. The process is guided by the T-lymphocyte's chemical instructions to the other immune system cells through lymphokines. There are numerous sub-types of T-cells including helper T-cells T-cytotoxic cells and T-suppressor cells. Most notable T-lymphocytes initiate direct and shut down the immune response to a specific antigen.
5. Macrophages can be thought of as "garbage collectors" that rid the body of worn-out cells and other debris. These cells likewise contain subtypes such as monocytes which circulate in the bloodstream looking for foreign material to ingest for disposal. The macrophage cell group also includes granulocytes that carry potent chemicals capable of destroying some microorganisms by spraying them or by ingesting and chemically destroying them.
The body's immune system is so incredibly diverse that this thorough process can be programmed for more that ten million antigens. Equally fascinating every person has a unique highly personalized pool of genetic and acquired immune memories. Once those memories are in place the body immediately "remembers" the specific antigen from previous invasions and takes decisive action. That's why varicella (chicken pox) is a one time illness.In the event that T-lymphocytes are either out-numbered or do not possess the chemical coding that recognizes an invader cell infection may spreads unabated. The results can be and often are life-threatening.
Nearly five decades of on-going research and testing have led to the discovery of the immune system's workings. While there's more to be learned immunologists have now developed highly potent and chemically "tailored" transfer factors to combat specific antigens (6 19-22). Immune-responsive donors are carefully studied to assure their status as such. Then through a human donor-to-animal-to-human recipient transfer process the antigen-specific immunity is delivered to the deficient patient. Remarkably those recipients are able to precisely emulate the immunity of the donor with significant results.
Until just a few years ago production of transfer factors was limited to very minute quantities. Now through intensive efforts researchers have developed and refined a process which mass produces products with transfer factors successfully (19 21 22). Targeted immunotherapy treatment is now possible for patients suffering from serious infections that were once thought to be untreatable.
In one study lifelong New York residents with presumably no prior antigen contact were given transfer factors of blood leukocytes from Californians who had delayed immune responses to coccidioidin. Rapaport's research showed that successful transfers had occurred in 28 of 35 recipients of transfer factors and results were seen within as little as 24 hours specifically for coccidioidin (4).
This led to an important question: Were transfer factors characteristics of a more random nature or as the Rapaport study showed were they consistently specific to a particular infection? The answer was confirmed through research conducted by Burger et al (5) in the mid 1970’s. Burger's unique study again using blood leukocytes strongly supported the ability of transfer factors to pass along immunities to specific antigens in those receiving treatment. The successful immunity transfer rate was 78% among 169 recipients tested. So instead of a "shot gun" approach where the only hope is to conquer the enemy with one big blast, transfer factors could be used as a sharply focused rifle with the ability to accurately target and "gun down" a particular enemy antigen.
Transfer factors immunotherapy has had its share of skeptics mainly because its exact structure and mechanism have yet to be completely understood. Yet significant results speak for themselves in cases of herpes simplex Epstein-Barr tuberculosis cytomegalovirus HIV and many others. This same phenomenon is reminiscent of the days when penicillin was initially viewed with skepticism. Ten years after its use began no one knew exactly how penicillin worked even though results were unmistakably positive.
One such theory is that autism is caused or exacerbated by heavy metal poisoning. Environmentally acquired heavy metals including mercury, either through some causal contact or through vaccination, have been postulated as a major culprit.(Mercury is used as a preservative in some types of vaccinations.) Mercury is thought to be exerting its neurological effect on the brain. There are of course other areas of causation that are also critically important. But autism as a form of mercury poisoning is one area that we need to take seriously.
The standard treatment parents of autistic children commonly use has been to apply medically prescribed chelating agents in an attempt to extricate the mercury.
But the human body has an amazing ability to detoxify itself when given the proper nutrients.“One missing component in the treatment is the utilization of the body’s own detoxification mechanisms,”notes autism/probiotic expert Mark Brudnak, Ph.D., N.D., author of the The Probiotic Solution (Dragondoor Publications, 2003) and developer of probiotics formulas. In several articles in the journal Medical Hypotheses,Dr. Brudnak combines several potential mechanisms associated with autism to construct a theory that explains how the condition could develop and progress, and how probiotics can help.
“Arguably,” he says,“the largest detoxification component of the body—the endogenous enteric bacteria—are an enormous reservoir, which can be constantly and safely replenished.”
Piecing Together the Puzzle of Autism: Linking the Digestive Tract to the Brain
Next, we went to Great Smokies Diagnostic Laboratory, which has been pioneering many different diagnostic tests that allow us to determine whether the gut flora of autistic children are in balance, and whether the intestinal tract suffers from excess permeability. Could there be a link between an imbalance of gut flora, intestinal permeability, and autism? (By permeability, we mean that the gut is leaky and is allowing undigested chemicals to pass directly through into the bloodstream. Some of these compounds are thought to be toxic and manifest their toxicity as autism symptoms.)
Childhood vaccinations have been implicated in the onset of autism, while diet has been implicated in its subsequent prognosis, Dr. Brudnak points out. A strong gut-brain connection is also apparent, with poor digestive function often appearing as a hallmark of the disorder.
According to the Great Smokies Connection newsletter:
“Dr. Brudnak speculates on the following chain of events. In early childhood, sensitivity to a vaccine, or a reaction to a mycobacterial infection, could disrupt pivotal molecular mechanisms that regulate how specific genes in the body switch ‘on’or ‘off’—what’s known as genetic expression. This may trigger malfunctioning of the immune and gastrointestinal systems, particularly in gut-associated lymphoid tissue,which Dr.Brudnak cites as ‘a major contributor to the pathological manifestations of autism.’
“When this happens, proteins are no longer properly broken down in the digestive tract. Cells in gut tissue die off prematurely, as the gut lining becomes ‘leaky’ and unable to repair itself. Compounds in the diet, like casein and gluten, normally kept at bay, may then permeate into the bloodstream. Their activated by-products, called exorphins, could act directly on the brain to trigger opioid-like effects associated with autistic symptoms.
“‘Such a scenario could explain why restoring healthy gut barrier function in autistic children is a treatment approach that ‘has met with a degree of success,’ Dr. Brudnak observes. Enzyme therapy (which improves the gut’s ability to break down proteins) and probiotics (supplementation with beneficial gut microbes that help repair the intestinal lining) have both produced positive clinical results in autistic children, he points out.
“In most cases symptoms of autism begin in early infancy. However, a subset of children appears to develop normally until a clear deterioration is observed. Many parents of children with ‘regressive’-onset autism have noted their children were given antibiotics immediately prior to the regression and that such use was followed by chronic diarrhea. This leads researchers to speculate that, in a subgroup of children, ‘disruption of indigenous gut flora might promote colonization by one or more neurotoxin-producing bacteria, contributing, at least in part, to their autistic symptomatology.’”
This line of thought stimulated recent research at the Section of Pediatric Gastroenterology and Nutrition, Rush Children’s Hospital,
Chronic Immune Reactivity May Damage Intestine
“The challenge that many chronic disorders pose to modern medicine is that they often emerge as an interrelated tapestry of imbalances within the human body, rather than in response to a single, isolated cause,” notes the newsletter, “And autism may be a prime example of this.”
Many children with autism have chronic digestive problems. In fact, gastrointestinal symptoms in autistic children often first appear in conjunction with initial changes in emotion and behavior during the onset of autism, leading researchers to suspect a gut-brain connection.
A recent study reported in the American Journal of Gastroenterology lends strong support to this possible gut-brain link. Researchers performed a colonoscopy on 60 children with autistic spectrum disorders who also had symptoms such as stomach pain, constipation, bloating, and diarrhea. The autistic children had much greater evidence of intestinal lesions than healthy children or non-autistic children with similar digestive problems.
Over 90 percent of autistic children showed clinical evidence of chronic enterocolitis, such as lymphoid nodular hyperplasia, a sixfold greater rate than found in the non-autistic children with inflammatory bowel disease.
“The pathology seems to reflect a subtle new variant of inflammatory bowel disease…” the researchers concluded, a type of “autistic enterocolitis.” Enterocolitis is an inflammation of the mucous membrane of the intestine. Researchers are not sure what could be causing the condition in children with autism, although it usually arises from chronic immune reactivity. In autism, such immune responses might be triggered by substances in the diet (eg., opioid eptides), viral agents (such as measles virus), mercury, or other causes, the researchers speculated.
The opioid peptide theory was first presented to the medical world in 1979. Excess peptides (breakdown products of dietary proteins) act as opioids affecting neurotransmitters within the central nervous system.
In the normal course of events, proteins are digested in stages by enzymes; first to peptides (the intermediate compounds), then to smaller amino acid components, which are absorbed into blood capillaries in the gut mucosa. The larger peptides are generally unable to cross this membrane barrier, but when they do, they can act as opioids affecting neurotransmitters in the brain causing abnormal behaviors and/or activity. This theory suggests a higher percentage of these opioid peptides reach the brain in autistic children.
These incompletely digested peptides—known as exorphins, casomorphins, and gluteomorphins—usually come from milk proteins such as casein or from wheat (gluten) and are structurally similar to morphine. In experimental studies, they have been shown to exert a morphine-like neurological influence. The formation of excess peptides in the gut is possibly associated with sub-optimal enzyme activity or an insufficient supply of enzymes required to breakdown these peptides. This may be genetic in origin, or caused by other factors, such as enzyme inactivity secondary to nutritional deficiency, or by altered gut microflora
So if we repair the imbalance of beneficial bacterial organisms in the gut and the gut lining, we have a chance to help some of our children with autism.
Indeed, a report from a dietician at the
“The gut-brain connection is now recognized as a basic tenet of physiology and medicine,” writes Eammonn M. M. Quigley, MD, in a related editorial,“ and examples of gastrointestinal involvement in a variety of neurological diseases are extensive.”
Did You Know—What is PDD?
Probiotics’ Role
Besides aiding repair of the gut lining and improving digestion,there is both anecdotal and clinical evidence that probiotics can help with detoxification, notes recent report from Clinical Pearls, one of the nation’s premiere nutrition newsletters. “Aerobic organisms have been shown to readily detoxify mercury. . . According to the
Obviously,we don’t know all the answers yet, but use of probiotics appears to be a promising lead in helping children with this very difficult-to-treat condition. If your child’s autism is accompanied by gastrointestinal distress, the potential for probiotics to help might be further amplified.
40 infantile Autistic patients were studied. They ranged from 6 years to 15 years of age at entry. 22 were classical infantile Autism; 18 lacked one or more clinical defects associated with infantile Autism. Of the 22 with classic Autism, 21 responded by gaining at least 2 points in symptoms severity score average (SSSA); 10 became normal in that they were mainstreamed in school and clinical characteristics were fully normalized. Of the 18 remaining, 4 responded to transfer factors; some to other therapies. After cessation of transfer factors therapy, 5 in the Autistic group and 3 of the pseudo-Autistic group reverted but dropped as low as baseline levels.
Dr. Bock gave an insightful lecture on autism and the different areas that play a part in its diagnosis and treatment. Autism can occur as a result of various factors: genetics, neuro/immunotoxicologic factors, metals, xenobiotics (like pesticides), abnormal liver function, nutritional deficiency, gastrointestinal abnormalities and a viral infection or auto-immunity. Each of these factors is equally important in the treatment of autism.
The immune system is an important aspect of bringing balance to the body, and specifically, to someone who has autism. Transfer Factors can be very effective because they have been shown to both boost and suppress the immune system. Dr. Bock recently conducted an important study on the use of Transfer Factors with children who have Autism Spectrum Disorders.
Transfer Factors Study with Autistic Children By Bock M.D.
9 children
ages: 2.9-9.9
average age: 5.07
These children were given three capsules containing transfer factors, three times daily, for three months. Each patient was assessed prior to the treatment, six weeks into the study, and at the completion of the three-month study. Dr. Bock used the Gilliam Autism Rating Scale for evaluation purposes. This method applies different scores based on: stereotyped "autistic" behaviors, communication, social interaction and developmental markers. These scores are then added together to determine an autism quotient. The higher the autism quotient is, the higher the degree of autism in the patient.
At the end of the three-month study, seven out of the nine autistic children had at least some improvement. Specifically, these improvements included:
- More attentive
- Eye contact improved
- Eczema improved
- Decreased incidence of illness
- Improved language skills
- Resolution of diarrhea
- Improved toileting skills
Although this study was small, Dr. Bock believes its results are very promising. He has included products with transfer factors as part of his treatment protocol and is excited about its possibilities for boosting the immune system in patients with autism as well as many other conditions he encounters on a daily basis.
Dr. Bock is a physician who is renowned for his integrated approach to health and wellness. For the past 17 years he has integrated alternative modalities with conventional medicine into what he calls Progressive Medicine.
He is the co-author of two books: The Road to Immunity and Natural Relief for your Child's Asthma.